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Steric and electronic limitations for the Dötz benzannulation of aromatic alkynes

✍ Scribed by James C. Anderson; John W. Cran; N.Paul King

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
84 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

As part of an investigation into a new strategy for biaryl synthesis, the Do ¨tz benzannulation of a series of substituted aryl acetylenes was undertaken to determine possible steric and electronic effects exerted by the aryl group. In the ortho position it was found that methyl, methoxy, chloro and N-amide substituents give moderate to good yields of product, whereas carbonyl derivatives and the nitro group are deleterious.

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