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Stereospecificity of the Dehydratase Domain of the Erythromycin Polyketide Synthase

โœ Scribed by Valenzano, Chiara R.; You, Young-Ok; Garg, Ashish; Keatinge-Clay, Adrian; Khosla, Chaitan; Cane, David E.


Book ID
127019540
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
165 KB
Volume
132
Category
Article
ISSN
0002-7863

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Mechanism and specificity of the termina
โœ Rajesh S Gokhale; Daniel Hunziker; David E Cane; Chaitan Khosla ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 957 KB

## Background: Polyketides are important compounds with antibiotic and anticancer activities. several modular polyketide synthases (pkss) contain a terminal thioesterase (te) domain probably responsible for the release and concomitant cyclization of the fully processed polyketide chain. because the