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Functional Orientation of the Acyltransferase Domain in a Module of the Erythromycin Polyketide Synthase †

✍ Scribed by Gokhale, Rajesh S.; Lau, Janice; Cane, David E.; Khosla, Chaitan


Book ID
126100536
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
169 KB
Volume
37
Category
Article
ISSN
0006-2960

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✍ Rajesh S Gokhale; Daniel Hunziker; David E Cane; Chaitan Khosla 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 957 KB

## Background: Polyketides are important compounds with antibiotic and anticancer activities. several modular polyketide synthases (pkss) contain a terminal thioesterase (te) domain probably responsible for the release and concomitant cyclization of the fully processed polyketide chain. because the