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Stereospecificity of flobufen metabolism in guinea pigs in vitro and in vivo: Phase I of biotransformation

✍ Scribed by Radim Kral; Lenka Skalova; Barbora Szotakova; Yogeeta N. Babu; Vladimir Wsol

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
121 KB
Volume
16
Category
Article
ISSN
0899-0042

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Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs
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## Abstract Stereoselective aspects of pharmacokinetics and metabolism of a chiral nonsteroidal antiinflammatory drug, flobufen, 4‐(2′, 4′‐difluorobiphenyl‐4‐yl)‐2‐methyl‐4‐oxobutanoic acid, were studied in male guinea pigs after p.o. administration of racemic flobufen (__rac__‐flobufen) at a dose

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In vitro and in vivo experiments to investigate possible stereospecific aspects of oracin reduction in relation to rat gender have been conducted. Incubation of oracin with rat microsomes, cytosol, and hepatocytes in the presence of various coenzymes and under aerobic or anaerobic conditions provide