We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a
✦ LIBER ✦
Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans
✍ Scribed by Marie Nicklasson; Sven Björkman; Bodil Roth; Maria Jönsson; Peter Höglund
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 146 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0899-0042
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