## Abstract A high performance liquid chromatographic method for the determination of the photodynamic chemotherapeutic agent 5,10,15,20βtetra(__m__βhydroxyphenyl)chlorin (mβTHPC) in human plasma following intravenous infusion is described. The procedure involves extraction of the drug in plasma wi
In vitro and in vivo metabolism of 5,10,15,20-tetra (m-hydroxyphenyl)chlorin in rats and humans
β Scribed by Hong Cai; Qiang Wang; Jinli Luo; C. K. Lim
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 40 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0269-3879
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a
## Background and objective: To optimize photodynamic therapy, it is necessary to know the distribution of photosensitizer in normal tissue as well as tumors and to know how well animal models match human. this study measured the biodistribution of meta-tetra(hydroxyphenyl) chlorin (mthpc) in three