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Stereospecific total synthesis of the potent synthetic pyrethroid NRDC 182

โœ Scribed by Hatch, Charles E.; Baum, Jonathan S.; Takashima, Toshiyuki; Kondo, Kiyosi


Book ID
121366514
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
755 KB
Volume
45
Category
Article
ISSN
0022-3263

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A concise and efficient TEA-mediated desymmetrization of meso-thioanhydride 6 with 5-ethoxy-5oxopentylzinc bromine has been developed, which affords a convenient strategy for the stereospecific total synthesis of (ยฑ)-biotin 1.