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A novel synthetic strategy for the stereospecific total synthesis of (±)-biotin

✍ Scribed by Fei Xiong; Xu-Xiang Chen; Zhi-Qian Liu; Fen-Er Chen

Book ID
104097833
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
238 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

A concise and efficient TEA-mediated desymmetrization of meso-thioanhydride 6 with 5-ethoxy-5oxopentylzinc bromine has been developed, which affords a convenient strategy for the stereospecific total synthesis of (±)-biotin 1.

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