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Stereospecific synthesis of (+)-biotin

โœ Scribed by Hiroshi Ohrui; Sakae Emoto


Book ID
104215138
Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
123 KB
Volume
16
Category
Article
ISSN
0040-4039

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## Abstract The total synthesis of the important natural product biotin **1** from the readily available keto diester **3** is described. This approach features the stereospecific hydrogenation of the thiophene intermediate **19** as the key synthetic step. The required differentiation of the diac