Stereospecific synthesis of an α-mannosidase inhibitor relatedto swainsonine
✍ Scribed by Philip DeShong; Daniel R. Sidler; David A. Kell; Nathan N. Aronson Jr.
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 122 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A stereospecific synthesis of pyrrolidine 2, an analog of swainsonine and an inhibitor of lysosomal a-D-mannosidase, is described.
📜 SIMILAR VOLUMES
Swainsonine ( ) is an important mannosidase inhibitor that has been examined clinically as an anticancer drug. The preparation of analogs of swainsonine bearing a hydroxymethyl group at C(3), i.e., (3R)-3-(hydroxymethyl)swainsonine [( ), (3R)-HMS] and (3S)-3-(hydroxymethyl)swainsonine [( ), (3S)-HMS
Swainsonine, an indolizidine alkaloid, found in plants of the genus Swainsona, has been shown to be a strong inhibitor in vitro of the a-D-mannosidase activity in normal human fibroblasts. Therefore, inhibition of a-D-mannosidase activity in extracts of harvested cells grown with swainsonine in the
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