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Stereospecific synthesis of an α-mannosidase inhibitor relatedto swainsonine

✍ Scribed by Philip DeShong; Daniel R. Sidler; David A. Kell; Nathan N. Aronson Jr.


Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
122 KB
Volume
26
Category
Article
ISSN
0040-4039

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✦ Synopsis


A stereospecific synthesis of pyrrolidine 2, an analog of swainsonine and an inhibitor of lysosomal a-D-mannosidase, is described.


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Swainsonine, an indolizidine alkaloid, found in plants of the genus Swainsona, has been shown to be a strong inhibitor in vitro of the a-D-mannosidase activity in normal human fibroblasts. Therefore, inhibition of a-D-mannosidase activity in extracts of harvested cells grown with swainsonine in the