Stereospecific microbial reduction of 4,5-dihydro-4-(4-methoxyphenyl)-6-(trifluoromethyl-1H-1)-benzazepin-2-one
β Scribed by Ramesh N. Patel; Robert S. Robison; Laszo J. Szarka; John Kloss; John K. Thottathil; Richard H. Mueller
- Book ID
- 103521835
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 635 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0141-0229
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π SIMILAR VOLUMES
In the title compound, C 11 H 14 N 2 O, the diazepine ring adopts a skewed boat conformation. The molecule is stabilized by N-HΓ Γ ΓO intermolecular hydrogen bonds, forming a zigzag chain parallel to the b axis.
The reaction of 3-mercapto-4-aryIideneamino-l,2,4triazoles 2b-d, 3a-d with ethyl bromoacetate and/or phenacyl bromide in hot DMF and triethylamine affords the stereochemically pure 7-acyl-6-aryl-6,7dihydro-5H-lt2, 4-triazolo[3,4-b][l, 3,4]thiadiazines
## Abstract 1,1,1βTrifluoroalkaneβ2,3βdione 3βoximes 1 easily obtainable from aldehyde dimethylhydrazones were reacted with several aldehydes and ketones in the presence of acetic acid to afford 4βtrifluoromethylβ4__H__β[1,5,2]dioxadines 3 in satisfactory yields. When the reaction was carried out i