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Stereospecific introduction of a vicinally functionalized angular methyl group. A synthesis of 1-valeranone

โœ Scribed by Wenkert, Ernest.; Berges, David A.


Book ID
120356025
Publisher
American Chemical Society
Year
1967
Tongue
English
Weight
353 KB
Volume
89
Category
Article
ISSN
0002-7863

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Total synthesis of (+)-spatol. A stereos
โœ Robert G. Salomon; Basudeb Basu; Subhas Roy; Ram B. Sharma ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 242 KB

A total synthesis of (+)-spat01 (1) was achieved which depends upon a novel stereospecific transformation of trans-2,3-epoxy-1,4-diols to generate the sensitive allylic vicinal cisdiepoxide in 1. Spat01 (l), a structurally and functionally complex minor metabolite produced by a tropical