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Total synthesis of (+)-spatol. A stereospecific construction of vicinal diepoxides from 2,3-epoxy-1,4-diols

✍ Scribed by Robert G. Salomon; Basudeb Basu; Subhas Roy; Ram B. Sharma

Book ID: 104233200
Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 242 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)80758-9

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✦ Synopsis

A total synthesis of (+)-spat01 (1) was achieved which depends upon a novel stereospecific transformation of trans-2,3-epoxy-1,4-diols to generate the sensitive allylic vicinal cisdiepoxide in 1.

Spat01 (l), a structurally and functionally complex minor metabolite produced by a tropical

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