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Stereospecific and Stereoselective Preparation of 2-(1-Hydroxyalkyl)-1-alkylcyclopropanols from α,β-Epoxy Ketones and Bis(iodozincio)methane

✍ Scribed by Kenichi Nomura; Koichiro Oshima; Seijiro Matsubara


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
144 KB
Volume
117
Category
Article
ISSN
0044-8249

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## Abstract 1,4‐Addition of bis(iodozincio)methane to simple α,β‐unsaturated ketones does not proceed well; the reaction is slightly endothermic according to DFT calculations. In the presence of chlorotrimethylsilane, the reaction proceeded efficiently to afford a silyl enol ether of β‐zinciomethyl

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## Abstract The 1,4‐addition of bis(iodozincio)methane to α,β‐unsaturated ketones proceeds in the presence of chlorotrimethylsilane and affords silyl enol ethers of β‐zincinomethyl ketone.