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Stereospecific activity of two glutamate analogs

✍ Scribed by Juan Manuel Araujo Alvarez; Enrique Querejeta; Aldo Oviedo; José G. Trujillo Ferrara

Book ID
102075803
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
128 KB
Volume
16
Category
Article
ISSN
0899-0042

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Rigid analogs of ACPD have been synthesized to mimick different potential conformations of ACPD in aqueous solution. One of them, (+)-ABHD-I is a competitive antagonist at mGluRla receptor with a KB value of 300 laM. Glutamic acid is a major excitatory amino acid and neurotransmitter in the central