Investigation of the stereoselective in vitro biotransformation of thalidomide using a dual cyclodextrin system in capillary electrophoresis A previously developed capillary electrophoresis method for the simultaneous separation and enantioseparation of thalidomide (TD) and its hydroxylated metaboli
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Stereoselectivity of the in vitro metabolism of thalidomide
โ Scribed by Beate Knoche; Dr. Gottfried Blaschke
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 343 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0899-0042
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The purposes of this work were (1) to develop a high performance liquid chromatographic (HPLC) assay for the enantiomers of thalidomide in blood, (2) to study their inversion and degradation in human blood, and (3) to study the phannacokinetics of (+)-(R)and (-)-(S)-thalidomide after oral administra