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Stereoselectivity of the in vitro metabolism of thalidomide

โœ Scribed by Beate Knoche; Dr. Gottfried Blaschke


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
343 KB
Volume
6
Category
Article
ISSN
0899-0042

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๐Ÿ“œ SIMILAR VOLUMES


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Investigation of the stereoselective in vitro biotransformation of thalidomide using a dual cyclodextrin system in capillary electrophoresis A previously developed capillary electrophoresis method for the simultaneous separation and enantioseparation of thalidomide (TD) and its hydroxylated metaboli

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The purposes of this work were (1) to develop a high performance liquid chromatographic (HPLC) assay for the enantiomers of thalidomide in blood, (2) to study their inversion and degradation in human blood, and (3) to study the phannacokinetics of (+)-(R)and (-)-(S)-thalidomide after oral administra