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Stereoselectivity of the carbonyl reduction of dolasetron in rats, dogs, and humans

✍ Scribed by James Dow; Christiane Berg

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
569 KB
Volume
7
Category
Article
ISSN
0899-0042

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## Abstract A stereospecific high‐performance liquid chromatographic (HPLC) method was developed for the quantitation of the enantiomers of venlafaxine, an antidepressant, in dog, rat, and human plasma. The procedure involves derivatization of venlafaxine with the chiral reagent, (+)‐S‐naproxen chl