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Stereoselectivity of muscarinic receptors in vivo and in vitro for oxotremorine analogs. N-[4-tert-amino-2-butynyl]-5-methyl-2-pyrrolidones

โœ Scribed by Amstutz, Rene; Ringdahl, Bjoern; Karlen, Bo; Roch, Margareth; Jenden, Donald J.


Book ID
120814847
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
807 KB
Volume
28
Category
Article
ISSN
0022-2623

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## Abstract 2โ€(4โ€Methoxyphenyl)โ€__N__โ€(4โ€methylbenzyl)โ€__N__โ€(1โ€methylpiperidinโ€4โ€yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5โ€HT~2A~ antagonist, was labeled by [^11^C]โ€methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor