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Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1′-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors

✍ Scribed by Bingzhi Shi; Tanjore K Narayanan; Zhi-Ying Yang; Bradley T Christian; Jogeshwar Mukherjee


Book ID
117688416
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
541 KB
Volume
26
Category
Article
ISSN
0969-8051

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✍ Jogeshwar Mukherjee; Tanjore K. Narayanan; Bradley T. Christian; Bingzhi Shi; Ke 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 3 views

The in vitro autoradiographic binding characteristics as well as in vivo imaging characteristics of a dopamine D2 receptor agonist, (R,S)-2-(N-propyl-N-1Ј-11 Cpropyl)amino-5-hydroxytetralin ( 11 C-5-OH-DPAT), were studied. In 3 H-spiperone assays using rat striata, 5-OH-DPAT exhibited an affinity of