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Stereoselectivity of Four (R)-Selective Transaminases for the Asymmetric Amination of Ketones

✍ Scribed by Francesco G. Mutti; Christine S. Fuchs; Desiree Pressnitz; Johann H. Sattler; Wolfgang Kroutil


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
218 KB
Volume
353
Category
Article
ISSN
1615-4150

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## Abstract A highly diastereoselective and enantioselective Michael addition of cyclohexanone, acetone and other ketones to nitroolefins was developed by the use of an amine organocatalyst based on bispidine. Additionally, a theoretical study of transition structures revealed that this bispidine‐b