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Stereoselectivity in the formation and radical reduction of cyclic bromoacetals, key intermediates for the synthesis of δ-hydroxy- and ε-hydroxy-α-methylcarboxylic acid esters

✍ Scribed by Hajime Nagano; Ayako Mikami; Tomoko Yajima

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 144 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01738-6

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✦ Synopsis

We report the stereoselectivity in the formation and radical reduction of six-and seven-membered cyclic bromoacetals. The oxidative ring cleavage of the resulting acetals gave the corresponding acyclic d-hydroxyand o-hydroxy-a-methylcarboxylic acid esters.

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