Stereoselective β-disubstituted enone synthesis from γ-alkoxy-alkynones.
✍ Scribed by John M. Gardiner; Philip E. Giles
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 288 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Reaction of alkyllithiums 1 with isoprene epoxide 2 gives B,y-disubstituted allylic alcohols 2 of Z-configuration. The reaction of \*-lithiotricyclene as alkyllithium gives o-santalol 5, which is one of the main constituents in East Indian sandalwood oil.
Cross-coupling reactions of various organocopper reagents with u-(mesyloxy)ailyls~lanes have been evaluated for stereoselectlve P,P-dlsubstltuted vinylsilane synthesis $2' displacements with RMgBdCuCN(cat ) reagents proceeded In high yields (84+94%) and E-selectlvltles (10 1 -+ 38 1) in THF at -78°C