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Stereoselective total synthesis of the cytotoxic lactone (−)-spicigerolide

✍ Scribed by Gowravaram Sabitha; Chintam Nagendra Reddy; Atla Raju; Jhillu Singh Yadav

Book ID
108284662
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
396 KB
Volume
22
Category
Article
ISSN
0957-4166

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📜 SIMILAR VOLUMES

Stereoselective synthesis of spicigeroli
Stereoselective synthesis of spicigerolide
✍ Eva Falomir; Juan Murga; Miguel Carda; J.Alberto Marco 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 166 KB

The first total synthesis of the naturally occurring, cytotoxic lactone spicigerolide is described. The commercially available sugar L-rhamnose was the chiral starting materal. Key steps in the synthesis were an aldehyde two-carbon homologation via the Corey-Fuchs protocol, an asymmetric Brown-type