Stereoselective total synthesis of protected sulfamisterin and its analogues

✍ Scribed by Å paková Raschmanová, Jana; Martinková, Miroslava; Gonda, Jozef; Uhríková, Alena

• Book ID: 120429741
• Publisher: Versita
• Year: 2013
• Tongue: English
• Weight: 343 KB
• Volume: 67
• Category: Article
• ISSN: 0366-6352
• DOI: 10.2478/s11696-013-0392-y

✦ Synopsis

Abstract

The stereoselective synthesis of sulfamisterin I and its unnatural analogues II and V in their protected form was achieved through a common strategy. The Wittig reaction of aldehydes VIII and IX with the C14 hydrophobic side-chain X served as the key C-C connecting transformation. Subsequent functional group inter-conversions in the coupling products XI and XX completed the total synthesis.