Stereoselective total synthesis of penaresidin A starting from d-galactal
β Scribed by Reddy, B.V. Subba; Kishore, Ch.; Reddy, A. Srinivas
- Book ID
- 123124629
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- French
- Weight
- 600 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The chiral and stereoselective synthesis of (+)-lactacystin 1, the first non-protein neurotrophic factor having an ct,~t-disubstituted a-amino acid structure, is described. The highly functionalized y-lactam portion possessing a tetra-substituted carbon with nitrogen in I was effectively constructed
Iodoeyclisation of 6-O-pivaloyl-D-galaetal followed by radical reduction at C-2 and SN 2 conversion to a 3-endo iodide gave in good yield a [2.2.1] bicyclic acetal which can be regioselectively opened by C-nucleophiles (aUyl silane or silyloxyfuran) in the presence of a Lewis acid to give 2,5-trans-