Stereoselective total synthesis of (±)-antheridic acid
✍ Scribed by Masanao Shimano; Hiroto Nagaoka; Yasuji Yamada
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 204 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
One of the foremest problems encountered in synthesis of diterpenoid resin acids is that of stereoselective introduction of methyl and carboxyl substituents at the quaternary k-position in the correct configuration relative to the C-10 angular methyl. Most previous syntheses
An effective route for the total synthesis of antheridic acid (1) has been devised in which the initial chiral intermediate 7 is generated by enantioselective catalytic reduction and transformed in a stereocontrolled fashion into key intermediates 9, 10, 13, and 2.