A route for the enantioselective total synthesis of antheridic acid, the antheridium-inducing factor from anemia phyllitidis

✍ Scribed by E.J. Corey; Hideo Kigoshi

• Publisher: Elsevier Science
• Year: 1991
• Tongue: French
• Weight: 189 KB
• Volume: 32
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)93418-x

✦ Synopsis

An effective route for the total synthesis of antheridic acid (1) has been devised in which the initial chiral intermediate 7 is generated by enantioselective catalytic reduction and transformed in a stereocontrolled fashion into key intermediates 9, 10, 13, and 2.