An improved synthesis of antheridic acid, the antheridium inducing factor from the fern anemia phyllitidis

A route for the enantioselective total s

A route for the enantioselective total synthesis of antheridic acid, the antheridium-inducing factor from anemia phyllitidis

✍ E.J. Corey; Hideo Kigoshi 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 189 KB

An effective route for the total synthesis of antheridic acid (1) has been devised in which the initial chiral intermediate 7 is generated by enantioselective catalytic reduction and transformed in a stereocontrolled fashion into key intermediates 9, 10, 13, and 2.