Stereoselective synthesis ofβ-amino acids via conjugate addition of nitrogen nucleophiles toα,β-unsaturated esters — Recent advances
✍ Scribed by N. Sewald
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 763 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0939-4451
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📜 SIMILAR VOLUMES
The conjugate addition of nitrogen nucleophiles to ct,13-unsaturated lactam lb under very mild conditions occurs in good yield with high diastereoselectivity. Deprotection provides a simple access to 13-aminopyrrolidinones in excellent overall yield.
We recently reported the first examples of conjugate additions of alkyl sulphoxides to unsaturated esters,\* These reactions proceed with good selectivity and provide a promising new method for carrying out
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