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Conjugate addition of nitrogen nucleophiles to an α, β-unsaturated pyrrolidinone

✍ Scribed by Philip W.H Chan; Ian F Cottrell; Mark G Moloney

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
236 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The conjugate addition of nitrogen nucleophiles to ct,13-unsaturated lactam lb under very mild conditions occurs in good yield with high diastereoselectivity. Deprotection provides a simple access to 13-aminopyrrolidinones in excellent overall yield.

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