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Stereoselective synthesis of β-lactams

✍ Scribed by Alan D. Brown; Ernest W. Colvin

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
127 KB
Volume
32
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient method for the preparation of chiral cis-3,4-disubstituted 8-1actams, based on reaction between imines from homochiral protected lactaldehydes and furfurylamine and phenyl dichlorophosphate activated carboxylic acid derivatives, is reported.

📜 SIMILAR VOLUMES

A Stereoselective Synthesis of Sugar-Der
A Stereoselective Synthesis of Sugar-Derived Chiral β-Lactams
✍ Rama Kanwar Khangarot; Krishna P. Kaliappan 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 525 KB

## Abstract The importance of the β‐lactam substructure is exemplified by the several classes of β‐lactam antibiotics. Among the synthetic routes available to obtain this interesting scaffold, the Kinugasa reaction is a convergent strategy. In this article, the synthesis of a variety of chiral β‐la