Stereoselective synthesis of tricyclic guanidine systems: confirmation of the stereochemistry of batzelladine F left-hand tricyclic guanidine portion
โ Scribed by Kazuo Nagasawa; Hiroyuki Koshino; Tadashi Nakata
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 65 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The stereoselective synthetic methods for anti-and syn-fused tricyclic guanidine compounds 4a and 4b were developed based on a successive 1,3-dipolar cycloaddition. Through these synthetic studies, the stereochemistry of the left-hand tricyclic guanidine unit of batzelladine F (3) was confirmed as a syn-fused one, which is identical with the structure reported by the Murphy and Snider groups.
๐ SIMILAR VOLUMES
Stereoselective and efficient synthesis of tricyclic guanidine, the key component of batzelladines A and D, was accomplished based on successive 1,3-dipolar cycloadditions and successive cyclizations for the construction of the tricyclic guanidine ring.