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Stereoselective synthesis of tricyclic guanidine systems: confirmation of the stereochemistry of batzelladine F left-hand tricyclic guanidine portion

โœ Scribed by Kazuo Nagasawa; Hiroyuki Koshino; Tadashi Nakata


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
65 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


The stereoselective synthetic methods for anti-and syn-fused tricyclic guanidine compounds 4a and 4b were developed based on a successive 1,3-dipolar cycloaddition. Through these synthetic studies, the stereochemistry of the left-hand tricyclic guanidine unit of batzelladine F (3) was confirmed as a syn-fused one, which is identical with the structure reported by the Murphy and Snider groups.


๐Ÿ“œ SIMILAR VOLUMES


Stereoselective synthesis of tricyclic g
โœ Kazuo Nagasawa; Takanori Ishiwata; Yuichi Hashimoto; Tadashi Nakata ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 70 KB

Stereoselective and efficient synthesis of tricyclic guanidine, the key component of batzelladines A and D, was accomplished based on successive 1,3-dipolar cycloadditions and successive cyclizations for the construction of the tricyclic guanidine ring.