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Stereoselective Synthesis of the Side Chains of Mycolactones A and B Featuring Stepwise Double Substitutions of 1,1-Dibromo-1-alkenes

โœ Scribed by Ning Yin; Guangwei Wang; Mingxing Qian; Eiichi Negishi


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
153 KB
Volume
45
Category
Article
ISSN
0044-8249

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Stereoselective Synthesis of the Side Ch
โœ Ning Yin; Guangwei Wang; Mingxing Qian; Eiichi Negishi ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 153 KB

We report herein a stereoselective synthesis of the side chains of mycolactones A (1 A) and B (1 B). These side chains 2 A and 2 B, respectively, are protected as a methoxymethyl (MOM) ether at C12 and tert-butyldimethylsilyl (TBS) derivatives at C13 and C15, and are thus ready to be used as interme