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Stereoselective Synthesis of the Monomeric Unit of Actin Binding Macrolide Rhizopodin

✍ Scribed by Pulukuri, Kiran Kumar; Chakraborty, Tushar Kanti


Book ID
111903694
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
921 KB
Volume
14
Category
Article
ISSN
1523-7060

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Stereoselective Synthesis of the Monomer
✍ J. RenΓ© Backes; Ulrich Koert πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 191 KB

## Abstract The monomeric unit of the macrodiolide SCH 351448 has been synthesized from three building blocks. Strategic disconnections were chosen between C21–C22 (Wittig) and C10–C11 (stereoselective aldol). The __cis__ configuration of both 2,6‐disubstituted tetrahydropyran rings was established