The Hepatotoxicity of Valproic Acid and
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G. Richard Granneman; Shyh-Ing Wang; James W. Kesterson; Joseph M. Machinist
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Article
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1984
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John Wiley and Sons
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English
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The role of metabolites in valproic acid (VPA)-associated hepatotoxicity was studied in rats. The most steatogenic mono-unsaturated metabolite, 4-en-VPA, caused the greatest changes in indicators of beta-oxidation inhibition (dicarboxylic aciduria, beta-hydroxybutyrate reduction); however, the bioch