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Stereoselective synthesis of the C1–C8 subunit of peloruside A

✍ Scribed by Raghavan, Sadagopan; Kumar, V. Vinoth


Book ID
120268710
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
657 KB
Volume
69
Category
Article
ISSN
0040-4020

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The C 15 -C 25 upper THP segment 2 of (+)-lasonolide A has been synthesized efficiently via diastereomeric differentiation, iodocyclization and Julia-Kocien ´ski's sulfone olefination to install its quaternary chiral center, cis-2,6-disubstituted THP and trans-olefin, respectively.