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A stereoselective synthesis of the C15–C25 subunit of (+)-lasonolide A

✍ Scribed by Sung Ho Kang; Hyeong-wook Choi; Cheol Min Kim; Hyuk-Sang Jun; Suk Youn Kang; Joon Won Jeong; Joo-Hack Youn

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
157 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

The C 15 -C 25 upper THP segment 2 of (+)-lasonolide A has been synthesized efficiently via diastereomeric differentiation, iodocyclization and Julia-Kocien ´ski's sulfone olefination to install its quaternary chiral center, cis-2,6-disubstituted THP and trans-olefin, respectively.

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