Stereoselective synthesis of the anomeric 5-mercapto-2′-deoxyuridines and of some other α- and β-deoxyribonucleosides
✍ Scribed by Thomas J. Bardos; Michael P. Kotick; Csaba Szantay
- Book ID
- 104250244
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- French
- Weight
- 311 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
5-Merceptourecil (I), en l ntimctabolite of thymine in 4. 1eichPvnnii (l), potsntiatam the inhibitory effecte of 5-fluorourecil end folic-* This invertigetion wee l upported by grent CA-06695 from the National Center Inetitute, U.S. Public EMelth Service, Betheede. y.
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The dUDP analogue, 2'-deoxyuridine 5'-(alpha,beta-imido)diphosphate (dUPNP) was synthesized. The corresponding triphosphate analogue (dUPNPP) was prepared by enzymic phosphorylation of dUPNP using the enzyme pyruvate kinase and phosphoenolpyruvate as the phosphate donor. This method was successful i
## Abstract Deuterium Labelled 5‐hydroxyindole‐3‐acetic acid and 5‐hydroxy‐tryptamine have been sythesized by a modification of the procedure previously described by Ek and Witkop (9) for the nondeuterated analogues. The deuterium is introduced by a solvent exahange reaction and by reduction with l