Stereoselective synthesis of tetrahydropyran and oxepane systems by the endo-cyclization of hydroxy styrylepoxides
โ Scribed by Hiroko Matsukura; Masamichi Morimoto; Hiroyuki Koshino; Ta-i Nakata
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 223 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
The behaviour in acid media of hydroxy selenides and hydroxy sulfides (la-c and l'a-c) was investigated. The protection of the primary hydroxyl group in compounds la and l'a allowed the stereoselective synthesis of a substituted tetrahydrofuran ring, whereas compounds lb-c and l'b-c gave an efficien
A new strategy for the construction of O-linked oxepane ring system is described. The present method involves regioselecti~e at.etal cleavage by i-Bu2AISePh and intramolecular radical cyclization by use of ~-alkoxyacrylate.