Convergent and stereoselective method for synthesis of O-linked oxepane ring system by intramolecular radical cyclization

✍ Scribed by Makoto Sasaki; Masayuki Inoue; Tetsuji Noguchi; Atsuo Takeichi; Kazuo Tachibana

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 237 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00338-4

✦ Synopsis

A new strategy for the construction of O-linked oxepane ring system is described. The present method involves regioselecti~e at.etal cleavage by i-Bu2AISePh and intramolecular radical cyclization by use of ~-alkoxyacrylate.