Stereoselective Synthesis of Tetra-Substituted Olefins via Addition of Zinc Enolates to Unactivated Alkynes.
✍ Scribed by Masaharu Nakamura; Taisuke Fujimoto; Kohei Endo; Eiichi Nakamura
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 42 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract α‐Alkylation of the α,β‐unsaturated ketone 1 at C‐4 has been achieved by thioalkylation of the corresponding zinc dienolate with α‐chlorosulfides of type 2. The desulfurization of the β‐(phenylthio) ketones 4 leads directly to the 4‐substituted hexahydroinden‐5‐ones 5. magnified image