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Stereoselective synthesis of substituted piperazines

✍ Scribed by J. Barluenga; C. Nájera; M. Yus


Book ID
112125742
Publisher
Journal of Heterocyclic Chemistry
Year
1979
Tongue
English
Weight
206 KB
Volume
16
Category
Article
ISSN
0022-152X

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A stereospecific synthesis of tetra-subs
✍ Raid J. Abdel-Jalil; Raed A. Al-Qawasmeh; Yousef Al-Abed; Wolfgang Voelter 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 123 KB

A one pot reaction of the epoxy triflates 1 or 2 with a variety of N,N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.