A stereospecific synthesis of tetra-substituted chiral piperazines

✍ Scribed by Raid J. Abdel-Jalil; Raed A. Al-Qawasmeh; Yousef Al-Abed; Wolfgang Voelter

• Book ID: 104259971
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 123 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01677-3

✦ Synopsis

A one pot reaction of the epoxy triflates 1 or 2 with a variety of N,N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.