Stereoselective synthesis of substituted pipecolic acids
β Scribed by Steven R. Angle; Damian O. Arnaiz
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 266 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
A new general method for the preparation of 2-alkyl-pipecolic acids has been developed. The syntheses of 2-methyl-, 2-benzyl-and cis-6-methylpipecolic acids are described. (-)S-and (+)R-2-methylpipecolic acids were resolved by fractional crystallization of the quinine salt of their N-carbobenzoxy de
Three protected 3-substituted pipecolic acid analogs were prepared as constrained chimeric amino acid building blocks. The concise synthetic route enables the synthesis of other derivatives with sidechaln functionality of amino acids as well.