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Stereoselective synthesis of spiro and condensed pyrazolines of steroidal α,β-unsaturated ketones and nitrilimines by 1,3-dipolar cycloaddition

✍ Scribed by Erzsébet Mernyák; Eszter Kozma; Anasztázia Hetényi; László Márk; Gyula Schneider; János Wölfling


Book ID
116892317
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
383 KB
Volume
74
Category
Article
ISSN
0039-128X

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Synthesis of spiro-1-pyrazolines by the
✍ Artur M. S. Silva; José A. S. Cavaleiro; Albert Lévai; Tamás Patonay 📂 Article 📅 1999 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 641 KB

## Abstract 1,3‐Dipolar cycloadditions of exocyclic α,β‐unsaturated ketones 1‐22 with diazomethane afforded spiro‐1‐pyrazolines 23‐44 in a diastereospecific reaction. The structure and stereochemistry of each compound synthesised has been elucidated by nmr spectroscopic measurements and other analy