Stereoselective synthesis of 5,6-disubst
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Ivan Jabin; Nicolas Monnier-Benoit; Stéphane Le Gac; Pierre Netchitaı̈lo
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Article
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2003
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Elsevier Science
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French
⚖ 196 KB
Atropisomeric 5,6-disubstituted-3,4-dihydro-1H-pyridin-2-ones have been synthesized stereoselectively from chiral imines through a Michael reaction and a subsequent stereoselective azacyclization. A thermal study has shown that epimerization of the chiral axis can not take place even at high tempera