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Stereoselective synthesis of new classes of atropisomeric compounds through a tandem Michael reaction–azacyclization process. Part 2

✍ Scribed by Stéphane Le Gac; Nicolas Monnier-Benoit; Lionel Doumampouom Metoul; Samuel Petit; Ivan Jabin


Book ID
108283690
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
333 KB
Volume
15
Category
Article
ISSN
0957-4166

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Stereoselective synthesis of 5,6-disubst
✍ Ivan Jabin; Nicolas Monnier-Benoit; Stéphane Le Gac; Pierre Netchitaı̈lo 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 196 KB

Atropisomeric 5,6-disubstituted-3,4-dihydro-1H-pyridin-2-ones have been synthesized stereoselectively from chiral imines through a Michael reaction and a subsequent stereoselective azacyclization. A thermal study has shown that epimerization of the chiral axis can not take place even at high tempera