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Stereoselective synthesis of 5,6-disubstituted-3,4-dihydro-1H-pyridin-2-ones, a new class of non-biaryl atropisomeric compounds. Part 1

✍ Scribed by Ivan Jabin; Nicolas Monnier-Benoit; Stéphane Le Gac; Pierre Netchitaı̈lo

Book ID: 104252684
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 196 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02583-2

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✦ Synopsis

Atropisomeric 5,6-disubstituted-3,4-dihydro-1H-pyridin-2-ones have been synthesized stereoselectively from chiral imines through a Michael reaction and a subsequent stereoselective azacyclization. A thermal study has shown that epimerization of the chiral axis can not take place even at high temperature.

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