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Stereoselective synthesis of (.+-.) methyl nonactate

✍ Scribed by Baldwin, Steven W.; McIver, J. M.


Book ID
121386839
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
406 KB
Volume
52
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES


Stereoselective synthesis of (Β±)-methyl
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A total synthesis of (+)-methyl nonactate from a chiral synthon obtained by enantioselective enzymatic transesterification is described. This new approach involves stereoselective reactions of aldolisation, reduction and intramolecular Michael addition and appears to be quite general since it could

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A General and Stereoselective Approach to Nonactate Esters and Isomers: A Versatile Synthesis of (+)-Methyl Nonactate. -The title compound (XIII), which is a subunit of the macrotetrolide antibiotic nonactin, is stereoselectively synthesized from the chiral hydroxyacetate (I) in 11 steps and 6.4% o