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Stereoselective Synthesis of (-)-Malyngolide, (+)-Malyngolide and (+)-Tanikolide Using Ring-Closing Metathesis.

✍ Scribed by Miguel Carda; Santiago Rodriguez; Encarnacion Castillo; Alejandro Bellido; Santiago Diaz-Oltra; J. Alberto Marco


Publisher
John Wiley and Sons
Year
2003
Weight
38 KB
Volume
34
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A Stereoselective S
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Stereoselective Synthesis of the Natural
✍ Miguel Carda; Santiago RodrΓ­guez; Florenci GonzΓ‘lez; EncarnaciΓ³n Castillo; Alici πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 150 KB πŸ‘ 1 views

The stereoselective synthesis of the naturally occurring lactones osmundalactone (-)-1 and muricatacin (-)-2 is described. The key steps in each synthesis are the stereoselective addition of a Grignard reagent to a suitably protected Ξ±hydroxy aldehyde and a ring-closing metathesis.