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Stereoselective Synthesis of Functionalized Pyrrolidines via a [3 + 2]-Annulation of N -Ts-α-Amino Aldehydes and 1,3-Bis(silyl)propenes

✍ Scribed by Restorp, Per; Fischer, Andreas; Somfai, Peter


Book ID
118035262
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
57 KB
Volume
128
Category
Article
ISSN
0002-7863

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Total Synthesis of (+)-Alexine by Utiliz
✍ Martina Dressel; Per Restorp; Peter Somfai 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 294 KB 👁 2 views

## Abstract A novel route towards the polyhydroxylated pyrrolizidine alkaloid (+)‐alexine has been developed. A key step in this synthesis is a highly stereoselective [3+2] annulation reaction of __N__‐Ts‐α‐amino aldehyde **7 a** (Ts=tosyl) and 1,3‐bis(silyl)propene **8 a** for the construction of